Fezolinetant is a selective neurokinin 3 receptor (NK3R) antagonist that blocks binding of neurokinin B (NKB) to kisspeptin/neurokinin B/dynorphin (KNDy) neurons to modulate neuronal activity in the thermoregulatory center, helping to restore thermoregulatory balance
Restoration of thermoregulatory balance by fezolinetant:15
Figure 1. Normal thermoregulation
Figure 2. Disruption of thermoregulatory balance due to reduced estrogen
Figure 3. Mechanism of action of fezolinetant
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