Does fezolinetant treat hot flashes (VMS) induced by medication?

Published

Currently, no information is available on the safety and efficacy of fezolinetant in individuals suffering from treatment-induced vasomotor symptoms (VMS)

  • The Phase 3 HIGHLIGHT 1 trial (NCT06440967) is ongoing to investigate the safety and efficacy of fezolinetant 45 mg for the treatment of moderate to severe VMS in women with Stage 0 to 3 hormone receptor positive (either HER-2+ or HER-2-) breast cancer who are receiving adjuvant endocrine therapy (tamoxifen 20 mg or daily aromatase inhibitors) with or without gonadotrophin releasing hormone (GnRH) agonists/antagonists for a minimum of four months and not receiving chemotherapy.1
  • OPTION-VMS (NCT06049797) is an ongoing real-world Phase 4 study to assess the change in VMS bother in women with a confirmed diagnosis of VMS who are initiating nonhormonal therapy, including fezolinetant.1 Participants with non-metastatic (Stage 0 to 3) breast cancer who have been prescribed adjuvant endocrine therapy (i.e., tamoxifen or aromatase inhibitors with or without GnRH analogues) and have maintained a stable treatment regimen for ≥ 3 months can be included.
  • There are currently no studies on the effect of fezolinetant on treatment-induced VMS in men.

  1. Data on file.

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