Fezolinetant has no known risk of drug-drug interaction (DDI) with tamoxifen, toremifene, raloxifene, clomiphene, ospemifene, letrozole, or exemestane, according to Drugs interaction results, LexiDrug, and DynaMed. There is a risk of DDI between fezolinetant and anastrozole and fezolinetant and bazedoxifene according to Drugs interaction results, but not LexiDrug and DynaMed
Johnson KA, Martin N, Nappi RE, et al. Efficacy and Safety of Fezolinetant in Moderate to Severe Vasomotor Symptoms Associated With Menopause: A Phase 3 RCT. J Clin Endocr Metab. 2023;108(8):1981-1997. Available at: https://doi.org/10.1210/clinem/dgad058.
Lederman S, Ottery FD, Cano A, et al. Fezolinetant for treatment of moderate-to-severe vasomotor symptoms associated with menopause (SKYLIGHT 1): a phase 3 randomised controlled study. Lancet. 2023;401(10382):1091-1102. Available at: https://doi.org/10.1016/s0140-6736(23)00085-5.
Neal-Perry G, Cano A, Lederman S, et al. Safety of Fezolinetant for Vasomotor Symptoms Associated With Menopause: A Randomized Controlled Trial. Obstet Gynecol. 2023;141(4):737-747. Available at: https://doi.org/10.1097/aog.0000000000005114.
Data on file.
Iwai M, Nielsen J, Miyagawa M, et al. In Vitro Evaluation of CYP-Mediated Metabolism of Fezolinetant and Pharmacokinetic Interaction Between Fezolinetant and Fluvoxamine in Healthy Postmenopausal Smokers and Nonsmokers. 2024; Available at: https://doi.org/10.1002/jcph.6157.
Linardi A, Damiani D, Longui CA. The use of aromatase inhibitors in boys with short stature: what to know before prescribing? Arch. Endocrinol. Metab. 2017;61(4):391-397. Available at: https://doi.org/10.1590/2359-3997000000284.
Grimm SW, Dyroff MC. Inhibition of human drug metabolizing cytochromes P450 by anastrozole, a potent and selective inhibitor of aromatase. Drug Metab. Dispos.: Biol. fate Chem. 1997;25(5):598-602.
Electronic Citation. Drug Interactions Checker. Available at: https://www.drugs.com/.
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