According to Drugs® and UpToDate® Lexidrug™ drug interaction results, there is a risk of interaction between estrogen and fezolinetant, which is proposed to relate to weak CYP1A2 inhibition by estrogen. Fezolinetant is contraindicated in individuals using CYP1A2 inhibitors
VEOZAH [package insert]. Northbrook, IL, USA: Astellas Pharma, Inc. Available at: https://www.astellas.com/us/system/files/veozah_uspi.pdf.
UpToDate® LexiDrugTM. Interactions. Available at: https://online.lexi.com.
Drugs.com®. Interaction Checker. Available at: https://www.drugs.com.
DynaMed®. Drug Interactions. Available at: https://www.dynamed.com.
Choules M, Nielsen J, Chappa A, Parasrampuria D, Otsuka Y, Bonate P. Physiologically-based pharmacokinetic (PBPK) analysis of the potential interaction between fezolinetant and estradiol. Poster presented at Simcyp Consortium; September 24-26, 2024; London, UK. Poster #4
Data on file.
Johnson KA, Martin N, Nappi RE, et al. Efficacy and Safety of Fezolinetant in Moderate to Severe Vasomotor Symptoms Associated With Menopause: A Phase 3 RCT. J Clin Endocr Metab. 2023;108(8):1981-1997. https://dx.doi.org/10.1210/clinem/dgad058.
Lederman S, Ottery FD, Cano A, et al. Fezolinetant for treatment of moderate-to-severe vasomotor symptoms associated with menopause (SKYLIGHT 1): a phase 3 randomised controlled study. Lancet. 2023;401(10382):1091-1102. https://dx.doi.org/10.1016/s0140-6736(23)00085-5.
Neal-Perry G, Cano A, Lederman S, et al. Safety of Fezolinetant for Vasomotor Symptoms Associated With Menopause: A Randomized Controlled Trial. Obstet Gynecol. 2023;141(4):737-747. https://dx.doi.org/10.1097/aog.0000000000005114.
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